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2’ OMe-A, 2’ OMe-C, 2’ OMe-G, 2’ OMe-U

The incorporation of 2'-O-Methyl RNA nucleotides induces a resistance to a wide variety of nucleases, in particular RNase. Furthermore, 2’-OMe oligonucleotides show slightly increased affinity towards their complementary mRNA target sequence, thereby forming more stable hybrid duplexes compared to their non-modified DNA or RNA counterparts. This enables the formation of more stable hybrids with complementary RNA strands than would be the case for non-modified DNA and RNA sequences.

 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
PAGE
Int X
X
X
X X
X
X
X = available/on stock
O = on request
 

2’ MOE-A, 2’ MOE-5-MeC, 2’ MOE-G, 2’ MOE-T

Oligonucleotides incorporating 2'-O-methoxyethyl (MOE)-modified nucleotides, can support most, if not all antisense mechanisms of action. Further key distinctive characteristics are nuclease resistance, lower toxicity, superior target binding specificity, as well as increased affinity towards complementary RNA. For more detailed information about 2'-MOE antisense oligonucleotides from Microsynth, please see the flyer under "Related Downloads".

 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
PAGE
Int X
X
X
O X
X
X
X = available/on stock
O = on request
 

2’ F-dA, 2’ F-dC, 2’ F-dG, 2’ F-dU

 
RNA analogue, which is not hydrolysis stable on the phosphate compared to RNA.
 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
PAGE
Int X
X
X
X X
X
X
X = available/on stock
O = on request
 

LNA-A, LNA-C (5mC), LNA-G, LNA-T

 
Locked Nucleic Acid (LNA) is a synthetic nucleic acid analogue containing a bridged, bicyclic sugar moiety. LNA:DNA hybrids show strongly improved annealing temperatures compared to their DNA:DNA counterparts
 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
PAGE
Int X
X
X
X X
X
X
X = available/on stock
O = on request